Modulation of Differentiation by Retinoids
نویسندگان
چکیده
منابع مشابه
Correlation between the Induction of Leukemic Cell Differentiation by Various Retinoids and Modulation of Protein Kinases1
During retinole acid induced differentiation of the human promyelocyte leukemia cell line 111.60and the human myeloblast cell line RDFD along the uni1lilid pathway, there is marked modulation of both the cyclic udenosine 3':5'-monophosphate dependent protein kinase and the phospholipid-scnsitivc calcium dependent protein kinase. In order to further assess whether these kinases are intimately as...
متن کاملCorrelation between the induction of leukemic cell differentiation by various retinoids and modulation of protein kinases.
During retinoic acid induced differentiation of the human promyelocyte leukemia cell line HL60 and the human myeloblast cell line RDFD along the myeloid pathway, there is marked modulation of both the cyclic adenosine 3':5'-monophosphate dependent protein kinase and the phospholipid-sensitive calcium dependent protein kinase. In order to further assess whether these kinases are intimately assoc...
متن کاملDifferentiation by Various Retinoids and Modulation of Protein Correlation between the Induction of Leukemic Cell
During retinole acid induced differentiation of the human promyelocyte leukemia cell line 111.60and the human myeloblast cell line RDFD along the uni1lilid pathway, there is marked modulation of both the cyclic udenosine 3':5'-monophosphate dependent protein kinase and the phospholipid-scnsitivc calcium dependent protein kinase. In order to further assess whether these kinases are intimately as...
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not hydrolysed to retinol in the rat in vivo or in HL-60 cells in vitro (A. B. Barua, J. Gallup & J. A. Olson, unpublished work). Secondly, it is not biologically active in stimulating rat growth; indeed it rather seems to enhance the appearance of deficiency signs in test animals (A. B. Barua & J. A. Olson, unpublished work). Nonetheless, it is active in stimulating the differentiation of HL-6...
متن کاملRole of retinoids in differentiation and carcinogenesis.
It has been known for more than 50 years that retinoids, the family of molecules comprising both the natural and synthetic analogues of retinol, are potent agents for control of both cellular differentiation and cellular proliferation (70). In their original clas sic paper describing the cellular effects of vitamin A deficiency in the rat, Wolbach and Howe clearly noted that there were distinct...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1983
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12540570